Search results for "Alar plate"

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Topography of somatostatin gene expression relative to molecular progenitor domains during ontogeny of the mouse hypothalamus

2010

The hypothalamus comprises alar, basal, and floor plate developmental compartments. Recent molecular data support a rostrocaudal subdivision into rostral (terminal) and caudal (peduncular) halves. In this context, the distribution of neuronal populations expressing somatostatin (Sst) mRNA was analyzed in the developing mouse hypothalamus, comparing with the expression pattern of the genes Orthopedia (Otp), Distal-less 5 (Dlx5), Sonic Hedgehog (Shh), and Nk2 homeobox 1 (Nkx2.1). At embryonic day 10.5 (E10.5), Sst mRNA was first detectable in the anterobasal nucleus, a Nkx2.1-, Shh-, and Otp-positive basal domain. By E13.5, nascent Sst expression was also related to two additional Otp-positiv…

endocrine systemBasal plate (neural tube)forebrain[SDV]Life Sciences [q-bio]OtpNeuroscience (miscellaneous)Shhlcsh:RC321-571lcsh:QM1-69503 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineArcuate nucleusmedicine[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular BiologySonic hedgehoghypothalamuslcsh:Neurosciences. Biological psychiatry. Neuropsychiatry[SDV.BDD]Life Sciences [q-bio]/Development BiologyOriginal Research030304 developmental biologyFloor plate0303 health sciencesAlar platebiologyDlk5forebrain;hypothalamus;Sst;Otp;Dlk5;Nkx2.1;Shh;in situ hybridization;CONTAINING NEURON SYSTEM;SONIC-HEDGEHOG;FOREBRAIN DEVELOPMENT;VENTRAL FOREBRAIN;DEVELOPMENTAL EXPRESSION;BRAIN-DEVELOPMENT;RAT HYPOTHALAMUS;GROWTH-HORMONE;CELL LINEAGES;DIENCEPHALONlcsh:Human anatomyCiencias naturales y ciencias de la saludSstNkx2.1medicine.anatomical_structureHypothalamusForebrainembryonic structuresNeuranatomybiology.protein[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]in situ hybridizationAnatomyNucleusNeuroscience030217 neurology & neurosurgery
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